АНТИФОЛАТИ ДЛЯ ПРОТИРАКОВОЇ ХІМІОТЕРАПІЇ. ЧАСТИНАІІ

V. A. Bacherikov

Анотація


В огляді розглянуто структури основних протиракових антифолатів, їх внутрішньоклітинні ферментні цілі, механізми їх протипухлинної дії. Детально обговорено фолатні антиметаболіти, отримані в останнє десятиліття і тенденції в пошуку високоефективних інгібіторів метаболічних шляхів фолієвої кислоти. Розглянуто переваги і обмеження антифолатів, які можуть бути використані в дизайні нових препаратів протипухлинної хіміотерапії.

Ключові слова


антифолати, антиметаболіти, протипухлинна хіміотерапія

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Посилання


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DOI: https://doi.org/10.18524/2304-0947.2013.4(48).37019

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