DOI: https://doi.org/10.18524/2304-0947.2018.3(67).140799

СИНТЕЗ ТА АФІНІТЕТ ДО ДНК 1-ДІАЛКІЛАМІНО-3- ІНДОЛО[ 2,3-b]ХІНОКСАЛІН-6-ІЛПРОПАН-2-ОЛІВ

O. S. Karpenko, O. О. Boyko, М. О. Shibinskaya, N. А. Kutuzova, S. А. Lyakhov

Анотація


Похідні індоло[2,3‑b]хіноксаліну (2) проявляють себе як противірусні та інтерфероногенні агенти, здатні до інтеркаляції у ДНК. Покращені умови синтезу та отримані нові похідні (3a-e) – гідроксивмісні аналоги 2 (m=n=1, X = CH2). Спектрофлуориметричним методом вивчений афінітет до ДНК сполук 3a-b. Показано, що вони мають дещо нижчі значення констант асоціації у порівнянні з похідними 2a-e, що не містять OH-групу.

Ключові слова


індоло[2,3‑b]хіноксалін; афінітет до ДНК; органічний синтез

Повний текст:

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Посилання


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Пристатейна бібліографія ГОСТ


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